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目的：探讨与肝丹主治功能有关的药理药效学作用及其特点。方法：2．2．15细胞株模型及改进方法；大鼠CCl4慢性肝损伤模型；小鼠腹腔巨噬细胞吞噬功能及血清溶血素含量实验。结果：动态观察13d肝丹对HB－sAg，HBeAg的最大抑制率为76．47％（d7），71．43％（d5），且呈现HBV分泌、复制越是旺盛，抑制作用越强的特点；肝丹组与模型组相比，肝功能明显改善［ALT（U／L）：39．80±7．91，72．00±17．42，P＜0．01；AST（U／L）：32．20±3．55，53．90±11．35，P＜0．001］，肝组织结构破坏轻，纤维组织增生程度轻，与乙肝宁组相比，各项指标变化略占优势；小鼠腹腔巨噬细胞吞噬功能增强，羊红细胞致敏的小鼠血清溶血素含量提高，显著优于空白对照组，与阳性对照组左旋咪唑相似。结论：肝丹具有抗HBV、保护肝细胞作用。
Objective: To explore the pharmacological and pharmacodynamic effects and characteristics of Gandandan’s attending function. METHODS: 2.2.15 cell strain model and improvement method; rats chronic liver injury model of CCl4; mouse peritoneal macrophage phagocytosis and serum hemolysin content experiments. RESULTS: The maximum inhibition rate of HB-sAg and HBeAg was 76.47% (d7) and 71.43% (d5), and the stronger the inhibitory effect was, the stronger the secretion and replication of HBV were. Liver function was significantly improved in liver Dan group compared with model group [ALT(U/L): 39.80±7.91, 72.00±17.42, P<0.01; AST(U/L) : 32.20±3.55, 53.90±11.35, P<0.001). The structure of liver tissue was lightly damaged and the degree of fibrous tissue proliferation was light. Compared with Yiganing group, the changes of various indexes slightly dominated. The phagocytic function of mouse peritoneal macrophages was enhanced, and the serum hemolysin content of sensitized sheep red blood cells was significantly higher than that of the blank control group, which was similar to that of the positive control group levamisole. Conclusion: Gandan has anti-HBV and hepatoprotective effects.