研究了腺苷－磷酸（ＡＭＰ）对豚鼠离体去内皮主动脉的松弛作用。并与腺苷进行了比较，ＡＭＰ和腺苷的ＥＤ５０分别是０．１２和０．１０ｍｍｏｌ·Ｌ－１．ＡＭＰ的作用可被腺苷脱氨酶抑制剂９－赤薄醇（２－羟基－３－壬基）腺嘌呤所增强；并可被５′－核苷酸外切酶抑制剂α，β－次甲基腺苷二磷酸抑制．后者还可抑制ＡＭＰ在豚鼠主动脉中的降解约５０％～８５％。这些结果提示。ＡＭＰ的松弛作用可能与其在′－核苷酸外切酶的作用下生成的降解产物腺苷有关，而其本身的作用十分微弱。 The relaxation of adenosine-phosphate (AMP) to the aortic endothelial cells of guinea pigs was studied. Compared with adenosine, the ED50 of AMP and adenosine were 0.12 and 0.10 mmol·L-1, respectively. The effect of AMP is potentiated by the adenosine deaminase inhibitor 9-tocopherol (2-hydroxy-3-nonyl) adenine; it can be enhanced by the 5’-exonuclease inhibitors α, β- Methionine diphosphate inhibition. The latter also inhibits the AMP in guinea pig aorta degradation of about 50% to 85%. These results suggest. The relaxing effect of AMP may be related to its degradation product adenosine, which is produced by the ’- exonuclease, but its own effect is very weak.