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目的:探讨观察孕期妇女采用个体化补充叶酸对其母婴结局的影响作用。方法:选取从2014年1月至2016年12月之间来院就诊的孕期妇女2000例纳入研究对象,将2000例孕期妇女通过盲选方法平均分为两组,即对照组与研究组;给予对照组孕期妇女常规补充叶酸,研究组孕期妇女则采用个体化补充叶酸;持续跟踪随访直至胎儿娩出。研究结束后比较分析两组的母婴结局。结果:(1)研究组孕期妇的母婴结局(妊娠并发症发生情况及胎儿不良结局发生情况)均明显低于对照组孕期妇女,P<0.05;(2)研究组孕期妇女的血清叶酸以及血浆HCY水平数值均明显优于对照组孕期妇女,P<0.05。结论:孕期妇女采用个体化补充叶酸对其母婴结局的影响作用显著,可以有效降低妊娠并发症的发生以及新生儿不良结局的发生,改善母婴结局,值得临床推广及应用。
OBJECTIVE: To investigate the effect of folic acid supplementation on maternal and infant outcomes in pregnant women. METHODS: Two hundred and seventy pregnant women who came to the hospital from January 2014 to December 2016 were enrolled in this study. 2000 pregnant women were divided into two groups equally by blind selection method: the control group and the study group; the control group Women in the group were routinely supplemented with folic acid, while women in the study group used individualized folic acid supplementation during pregnancy. The patients were followed up until the fetus was delivered. After the study compared the two groups of maternal and infant outcomes. Results: (1) The maternal and infant outcomes (incidence of pregnancy complications and fetal unpleasant outcome) in study group were significantly lower than those in control group during pregnancy (P <0.05). (2) Serum folic acid Plasma HCY levels were significantly better than the control group during pregnancy women, P <0.05. Conclusion: The effect of individualized folic acid supplementation on the outcome of mother and baby is significant. It can effectively reduce the occurrence of pregnancy complications and neonatal unhealthy outcomes, and improve the outcomes of maternal and infant. It is worthy of clinical promotion and application.