目的　联合应用经阴道配子移植和体外受精 (胚胎移植治疗至少一侧输卵管正常的不孕症。方法 2 9例均用超促排卵方法 ,经阴道向输卵管内插管注入卵母细胞和精子 ,其余卵母细胞行体外受精培养 ,于取卵后 48h将胚胎移入宫腔内。结果2 9例患者共 32个治疗周期 ,每周期平均植入卵子数 (3 4± 0 9)个 ,植入胚胎数 (3 3± 1 1)个。 32个周期中 12次妊娠 (37 5% ) ,其中宫内孕 8次、输卵管妊娠 4次 ;2次胚胎停止发育 ,6例已足月分娩。结论联合应用经阴道配子移植和体外受精 (胚胎移植治疗至少一侧输卵管正常的不孕症获得了良好的临床妊娠。 Objective To evaluate the efficacy of transvaginal gametes transplantation and in vitro fertilization (embryo transfer) for the treatment of infertility with normal tubal at least one side.Methods Twenty-nine cases were treated with hyperstimulation by intravaginal injection of oocytes and sperm into the oviduct, Oocytes were in vitro fertilized and transplanted into the uterine cavity 48h after ovulation.Results Twenty-nine treatment cycles were performed in 29 patients, with an average number of eggs (34 ± 0 9) implanted per cycle and implantation of embryos (3 3 ± 1 1), 12 pregnancies (37 5%) in 32 cycles, including 8 intrauterine pregnancies and 4 tubal pregnancies, 2 embryos stopped development and 6 cases had full-term delivery.Conclusion Combined Vaginal gametes transplantation and in vitro fertilization (embryo transfer treatment of tubal at least one side of the normal infertility achieved a good clinical pregnancy.