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目的观察雾化吸入碳酸氢钠液治疗煤工尘肺并慢性阻塞性肺疾病急性加重患者疗效。方法 164例煤工尘肺并慢性阻塞性肺疾病急性加重患者随机分成实验组和对照组各82例,对照组用常规抗感染、祛痰、常规雾化等治疗;实验组在对照组的基础上加用碳酸氢钠雾化,疗程均为一周。结果实验组呼出气冷凝液(EBC)中的pH值在治疗后明显升高且与治疗前相比差异有统计学意义(P<0.01),而对照组治疗前后相比差异无统计学意义(P>0.05);肺功能检测结果不论是实验组和对照组在治疗前后均无统计学意义(P>0.05);平均住院日实验组明显缩短,差异有统计学意义(P<0.01)。结论应用雾化碳酸氢钠治疗煤工尘肺并慢性阻塞性肺疾病急性加重期患者,可以明显提高疗效,缩短住院时间,很好地提高经济效益和社会效益,值得推广应用。
Objective To observe the effect of inhalation of sodium bicarbonate solution on patients with pneumoconiosis and acute exacerbation of chronic obstructive pulmonary disease. Methods 164 cases of pneumoconiosis with COPD and acute exacerbation of chronic obstructive pulmonary disease were randomly divided into experimental group and control group with 82 cases in each group. The control group was treated with routine anti-infective, expectorant and conventional aerosolization. On the basis of the control group Add sodium bicarbonate atomization, treatment are a week. Results The pH value of exhaled breath condensate (EBC) in the experimental group was significantly higher after treatment than that before treatment (P <0.01), while there was no significant difference in the control group before and after treatment (P < P> 0.05). There was no significant difference in the lung function test between the experimental group and the control group before and after treatment (P> 0.05). The average length of stay in the experimental group was significantly shorter (P <0.01). Conclusion The application of atomized sodium bicarbonate in patients with pneumoconiosis and chronic obstructive pulmonary disease in patients with acute exacerbation can significantly improve the efficacy and shorten the hospital stay and improve the economic and social benefits, which is worth popularizing and applying.