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目的观察不同剂量清开灵注射液对肝癌化疗栓塞术后发热的防治疗效。方法将132例经肝动脉灌注化疗栓塞的原发性和转移性肝癌患者随机分为常规对照组和小、中、大剂量清开灵治疗组。于介入治疗后当天,分别予常规治疗,常规治疗+小、中、大剂量(20、40、60 ml)清开灵注射液,静脉滴注,1次/d,连续10 d。结果中、大剂量清开灵组能明显降低体温或防止发热,缩短发热时间,并能明显减轻肝区疼痛、腹胀便秘、恶心呕吐及改善肝功能,与小型量清开灵组及常规对照组比较,疗效有明显差异(P<0.05~0.01);且大剂量清开灵组较中剂量清开灵组有明显疗效(P<0.05);小剂量清开灵组在疗效方面虽较常规对照组为优,差异无统计学意义(P>0.05)。结论中、大剂量清开灵注射液对肝癌化疗栓塞术后发热有明显防治疗效。且大剂量清开灵注射液较中剂量消开灵注射液疗效为优。
Objective To observe the curative effect of different doses of Qingkailing injection on fever after chemoembolization of liver cancer. Methods 132 patients with primary and metastatic HCC who underwent hepatic arterial chemoembolization were randomly divided into routine control group and small, medium and large dose Qingkailing treatment group. On the day after interventional therapy, routine treatment, routine treatment + small, medium and large dose (20,40,60 ml) Qingkailing injection, intravenous infusion, once a day for 10 days. Results, high-dose Qing Kai Ling group can significantly reduce body temperature or prevent fever, shorten the fever time, and can significantly reduce liver pain, abdominal distension constipation, nausea and vomiting and improve liver function, and a small amount of Qingkailing group and conventional control group (P <0.05 ~ 0.01); and high-dose Qingkailing group than the medium-dose Qingkailing group had a significant effect (P <0.05); low-dose Qingkailing group in the efficacy compared with conventional control Group was excellent, the difference was not statistically significant (P> 0.05). Conclusion, large doses of Qing Kai Ling injection of chemotherapy for liver cancer after chemoembolization has significant prevention and treatment of fever. And large doses of Qing Kai Ling injection than the dose of Xiao Ka Ling injection efficacy is excellent.