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有机磷杀虫剂的急性、亚急性毒性实验中,观察到受试动物视网膜电图(ERG)a波和b波振幅降低。曾报道长期接触有机磷农药可使动物或人发生睫状肌和视神经变性。本文研究长期接触倍硫磷对大鼠视网膜的慢性毒作用。实验组为40只雄性有色大鼠和20只白色大鼠,体重约为150g。对照为20只雄性有色大鼠和15只雄性白色大鼠。皮下注射给药,每周两次,每次50mg/kg。为期一年的实验中,每鼠的总剂量为1.6～1.8g。实验过程中,视网膜电图每3个月检查一次,眼底每日检查一次,组织学检查每3个月一次,在第3个月
In acute and subacute toxicity experiments of organophosphate insecticides, a and b-wave amplitude reduction of the electro-retinoic acid (ERG) of experimental animals was observed. It has been reported that long-term exposure to organophosphorus pesticides can cause ciliary muscle and optic nerve degeneration in animals or humans. This article studies long-term exposure to fenthion on the rat’s chronic retinal toxicity. Experimental group of 40 male rats and 20 white rats, weighing about 150g. The control was 20 male, colored rats and 15 male, white rats. Subcutaneous injection, twice a week, each 50mg / kg. A one-year experiment, the total dose of each mouse is 1.6 ~ 1.8g. During the experiment, the electroretinogram was examined every 3 months, the fundus was examined daily, the histology was examined every 3 months, and in the 3rd month