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过氧化物酶体增殖物激活受体-γ(PPAR-γ)是核受体家族成员之一,是参与脂肪细胞分化、糖脂代谢与动脉粥样硬化炎症过程的关键性转录因子,具有多种生理性效应。近期国内外研究发现其参与了动脉粥样硬化(A S)血管壁炎症反应的形成与发展的调控,PPAR-γ也可能具有致A S的作用。PPAR-γ在病理学和病理生理学的重要性引起该领域的研究热潮。本文综述PPAR-γ的结构配体及作用机制等,论述PPAR-γ与A S的炎性过程关系,详细阐明PPAR-γ影响氧自由基而调节A S的炎性过程。
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a member of the nuclear receptor family and is a key transcription factor involved in adipocyte differentiation, glycolipid metabolism and atherosclerotic inflammatory processes with more Physiological effects. Recent domestic and foreign studies have found that it is involved in the regulation of the formation and development of atherosclerosis (A s) vascular wall inflammation. PPAR-γ may also contribute to Aβ. The importance of PPAR-γ in pathology and pathophysiology has caused a wave of research in this area. This review summarizes the structural ligands and mechanisms of PPAR-γ, discusses the inflammatory processes of PPAR-γ and Aβ, and clarifies that PPAR-γ affects the oxygen free radicals and regulates the inflammatory process of Aβ.