肝脏能合成除因子Ⅲ及因子ⅩⅢ a 链以外的全部凝血因子以及凝血抑制物和纤溶酶原抑制物,并能降解活化的凝血因子及纤溶酶。因此,肝脏在维持凝血系统的正常功能上起着极为重要的作用。本文就近年来肝病凝血障碍发生机理的进展情况介绍如下:一、凝血因子合成减少肝病时凡在肝内合成的凝血因子均可减少,急慢性肝病时Ⅱ、Ⅴ、Ⅶ、Ⅸ、Ⅹ和Ⅺ、Ⅻ因子均降低,常以Ⅶ因子降低最显著,甚至轻度肝损伤即可发生凝血因 The liver can synthesize all clotting factors except coagulation inhibitors and plasminogen inhibitors in addition to factor Ⅲ and factor XIII a chain, and can degrade activated coagulation factors and plasmin. Therefore, the liver plays a very important role in maintaining the normal function of the coagulation system. In this paper, in recent years, the progress of the pathogenesis of hepatic coagulation disorders are described below: First, the synthesis of coagulation factors to reduce liver disease in the synthesis of hepatic coagulation factors can be reduced, acute and chronic liver disease Ⅱ, Ⅴ, Ⅶ, Ⅸ, Ⅹ and Ⅺ, Ⅻ factors are reduced, often to reduce the most significant factor Ⅶ, even mild liver injury can occur clotting factor