6-甲基腺嘌呤(N6-methyladenosine，mn 6A)是真核生物mRNA中最丰富的内部化学修饰，参与了许多转录后的调控过程，包括维持mRNA的稳定性、促进其剪接和翻译。在哺乳动物中，mn 6A的动态变化调节动物的生长、发育和代谢。相反，营养和饮食也可以通过调节mn 6A甲基化模式来调节基因表达。本文主要专注于mn 6A修饰与营养生理和代谢之间的相互作用研究。n “,”N6-methyladenosine(mn 6A)is the most abundant internal modification of mRNAs in eukaryotes and involved in many post-transcriptional regulatory processes, including mRNA stability, splicing and promotion of translation.In mammals, the dynamic alteration of mn 6A regulates the growth, development and metabolism of animals.Conversely, nutrition and diet can tune gene expression by modulating mn 6A methylation patterns.In this review, we highlight the crosstalk between mn 6A modification, nutritional physiology and metabolism.n