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目的:探索利用酸水解法制备甘草素的工艺。方法:首先证明甘草苷单体可酸水解产生甘草素,再利用酸水解甘草中甘草苷的方法制备甘草素。实验过程中利用薄层色谱、紫外分光光度法、高效液相色谱等辅助手段判断该方法的可行性。结果:甘草苷单体水解成甘草素的转化率为81.1%,甘草药材中甘草苷转化为甘草素转化率为63.2%。结论:酸水解制备甘草素的方法可行、简便且提取率高。
Objective: To explore the use of acid hydrolysis of liquiritigenin technology. Methods: It was firstly proved that the glycyrrhizin monomer can be acid-hydrolyzed to produce the liquiritigenin, and then the liquiritigenin was prepared by the acid hydrolysis of the liquiritin in the liquorice. During the experiment, the feasibility of this method was judged by the means of thin layer chromatography, ultraviolet spectrophotometry and high performance liquid chromatography. Results: The conversion rate of liquiritin to liquiritigenin was 81.1%. The conversion of liquiritin to liquiritigenin in licorice was 63.2%. Conclusion: The method of acid hydrolysis to prepare liquiritigenin is feasible, simple and high extraction rate.