有关羧乙基锗倍半氧化物(Ge-132)的研究情况,国内外均有很多报道,Ge-132毒性极低,动物实验各种途径给药半数致死量均在数克/公斤体重以上,各种毒性实验呈阴性结果.Ge-132在部分测 试系统显示了一定的抗诱变作用,但对真核生物生殖细胞的远期效应未见报道.本研究用Ge-132在果蝇测试系统进行了伴性隐性致死(SLRL)实验及抗SLRL实验,得到有价值的结果.实验采用黑腹果蝇(Drosophila Melanogaster)的野生型原种Oregon K品系和Basc Muller-5品系,预试结果如下:表 There are many reports at home and abroad about the research on the carboxyethyl germanium sesquioxide (Ge-132). The Ge-132 is very low in toxicity. The lethal doses for all routes of animal experiments are above the gram / kg body weight , All kinds of toxicity test was negative results.Ge-132 in some of the test system showed some anti-mutagenic effect on eukaryotic germ cells but no long-term effects have been reported.In this study, Ge-132 in the fruit fly test Systemic SLRL experiments and anti-SLRL experiments were carried out to obtain valuable results.We used Oregon K and Basc Muller-5 strains of wild type Drosophila Melanogaster, The results are as follows: Table