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我是一名病理科医生,看过许多尸体标本。用肉眼观察儿童主动脉标本,可以发现有黄色、微高起于内膜、如针头帽大到数毫米大的圆形斑点(脂点),或数毫米、数厘米长的与动脉纵轴平行的纵纹(脂纹)。显微镜下观察,在脂点、脂纹的病灶内,除在内膜可见泡沫状细胞聚积及细胞内、外有脂质外,在比较大的病灶用免疫萤光法和电子显微镜观察还发现有纤维素的存在。这些脂点、脂纹就是血脂侵入内膜后所发生的最早期病变,说明动脉粥样硬化的形成是从儿童期开始的。
I am a pathologist and have seen many body specimens. Visual observation of children with aortic specimens, can be found yellow, slightly elevated from the intima, such as the needle cap to a few millimeters large round spots (fat spots), or a few millimeters, several centimeters long parallel to the longitudinal axis of arteries The vertical stripes (fat pattern). Microscopic observation, in the fat spots, lipid pattern lesions, in addition to visible in the endomembrane cells accumulation and intracellular and extracellular lipid, in the larger lesions by immunofluorescence and electron microscopy also found that The presence of cellulose. These fat spots, lipid pattern is the earliest lesions occurred after blood lipids into the intima, indicating that the formation of atherosclerosis from childhood.