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目的:通过检测干细胞标记物Oct4在口腔黏膜白斑中的表达水平,探讨Oct4在口腔黏膜白斑癌变进程中的作用。方法:采用免疫组织化学SP法检测Oct4在10例口腔正常黏膜,40例扁平苔藓,60例白斑,20例鳞癌中表达水平;同时检测Oct4在30例癌变与30例未癌变白斑中的表达差异。结果:Oct4在正常黏膜中不表达,在扁平苔藓、白斑和鳞癌中的表达率分别为22.5%,56.7%和85.0%(P<0.05);Oct4在未癌变和癌变白斑中的表达率均为36.7%(P<0.01)。结论:Oct4与口腔黏膜恶性潜能程度相关,可能直接参与白斑癌变进程。
OBJECTIVE: To investigate the role of Oct4 in the carcinogenesis of oral leukoplakia by detecting the expression of stem cell marker Oct4 in oral leukoplakia. Methods: The expression of Oct4 in 10 normal oral mucosa, 40 lichen planus, 60 leukoplakia and 20 squamous cell carcinoma was detected by immunohistochemical SP method. Meanwhile, the expression of Oct4 in 30 cancerous lesions and 30 non-cancerous lesions difference. Results: The expression of Oct4 in normal mucosa was 22.5%, 56.7% and 85.0% in lichen planus, leukoplakia and squamous cell carcinoma respectively (P <0.05). The positive expression rate of Oct4 in non-cancerous and leukoplakia Was 36.7% (P <0.01). Conclusion: Oct4 is associated with the malignant potential of oral mucosa and may directly participate in the carcinogenesis of leukoplakia.