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目的探讨体重指数(BMI)与早期移植肾功能的关系。方法回顾性研究2003年11月至2014年11月在新疆医科大学第一附属医院肾病科接受同种异体活体肾移植的133例受者的临床资料。根据移植前的BMI将受者分为3组,消瘦组(BMI<18.5 kg/m2)、正常体重组(BMI18.5~23.9 kg/m2)、超重肥胖组(BMI>23.9 kg/m2)。比较3组受者术后1周的实验室指标[血尿素氮(BUN)、血清肌酐(Scr)、血红蛋白、血清白蛋白、总胆固醇和甘油三酯]、移植肾功能延迟恢复发生率,并对肾移植受者Scr与BMI进行相关分析。结果 3组受者的Scr水平比较差异有统计学意义(P<0.05);两两比较,超重肥胖组Scr水平高于正常体重组,差异有统计学意义(Z=-3.408,P=0.01)。3组肾移植受者血红蛋白、血清白蛋白、总胆固醇水平差异均无统计学意义(均为P>0.05)。肾移植受者Scr水平与BMI呈正相关(r=0.187,P=0.031),Scr水平随BMI增加而升高。结论 BMI影响早期移植肾功能恢复,肾移植术前控制体重,有助于改善移植肾功能。
Objective To explore the relationship between body mass index (BMI) and early graft function. Methods The clinical data of 133 recipients who underwent allogenic renal transplantation in Department of Nephrology, the First Affiliated Hospital of Xinjiang Medical University from November 2003 to November 2014 were retrospectively studied. The recipients were divided into 3 groups: BMI <18.5 kg / m2, BMI 18.5-23.9 kg / m2, and BMI> 23.9 kg / m2 according to BMI before transplantation. The laboratory indexes (BUN, SCr, hemoglobin, serum albumin, total cholesterol and triglyceride) of 1 week postoperatively in 3 groups were compared, and the incidence of delayed graft recovery was compared. The renal transplant recipients Scr and BMI correlation analysis. Results There was significant difference in Scr between the three groups (P <0.05). Scr level in overweight and obesity group was higher than that in normal group (P <0.05), the difference was statistically significant (Z = -3.408, P = 0.01) . There was no significant difference in hemoglobin, serum albumin and total cholesterol between the three groups (all P> 0.05). The level of Scr in renal transplant recipients was positively correlated with BMI (r = 0.187, P = 0.031). The level of Scr increased with the increase of BMI. Conclusion BMI can affect the function of early grafted kidney and control the weight before kidney transplantation, which may help to improve renal function.