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目的观察左炔诺孕酮宫内缓释系统(1evonorgestrel intrauterine system,LNG-IUS)临床使用的抗生育效果、不良反应并探讨其使用的安全性。方法对100例要求避孕的妇女随机分为两组,放置LNG-IUS(LNG组)与放置宫内节育器(intrauterine contraceptive device,IUD)—MCu IUD(MCu组)各50例,定期随访。并对放置LNG-IUS后闭经的17例妇女进行血清生殖激素水平的测定。结果 LNG组因闭经及面部长斑各停用1例。LNG组有1例放置3月后妊娠,MCu组有3例妊娠,差异无统计学意义(P>0.05)。两组妇女在节育器的脱落率、出血及疼痛情况方面的比较差异无统计学意义(P>0.05)。17例闭经妇女生殖激素水平与对照组比较差异无统计学意义(P>0.05)。结论 LNG-IUS导致的闭经是药物对子宫内膜局部作用,是可逆的,对女性生殖内分泌功能影响小,是一种可长期使用、安全有效的避孕系统。
Objective To observe the anti-fertility effect and adverse reactions of levonorgestrel intrauterine system (LNG-IUS) and to explore the safety of its use. Methods A total of 100 women who required contraception were randomly divided into two groups, 50 LNG-IUS (LNG group) and IUD-MCu IUD (MCu group) were placed in each group. Serum reproductive hormone levels were measured in 17 women with amenorrhea after LNG-IUS placement. Results In LNG group, 1 patient was disabled by amenorrhea and facial plaques. One patient in LNG group was pregnant after 3 months, and 3 patients in MCu group had no significant difference (P> 0.05). There was no significant difference in the rate of shedding, bleeding and pain among the two groups of women (P> 0.05). 17 cases of amenorrhea women reproductive hormone levels compared with the control group no significant difference (P> 0.05). Conclusion Amenorrhea caused by LNG-IUS is a drug that has a local effect on the endometrium and is reversible. It has little effect on female reproductive and endocrine functions and is a long-term, safe and effective contraceptive system.