苄普地尔(bepridil)是一个具有多种药理作用的新型、长效抗心绞痛药。增加心肌氧供应,减少心肌氧需要。除抑制钙经电压依赖性钙通道流入外,在细胞膜和细胞内还有其他作用,故比一般钙拮抗剂负性肌力作用和降压作用小,抗心绞痛作用则更强,并有抗心律失常作用。细胞膜作用抑制慢钙通道这一作用阻滞钙流入,降低窦房结自律性,减慢心率,延长房室结传导和PR间期。抑制快钠通道这一作用具有pH值依赖性(利多卡因样作用,I_b类效应),当pH值下降时该抑制作用增强;故当心肌缺血时它 Bepridil is a new, long-acting anti-anginal drug with multiple pharmacological actions. Increase myocardial oxygen supply, reduce myocardial oxygen demand. In addition to inhibiting the calcium-dependent voltage-dependent calcium channel into the outside, in the cell membrane and cells have other roles, so than the general calcium antagonist negative inotropic effect and antihypertensive effect is small, anti-anginal effect is stronger, and anti-rhythm Disorders. The role of cell membrane inhibition of calcium channel block calcium influx, reduce sinus node autonomic, slow heart rate, prolong the AV node conduction and PR interval. The effect of inhibiting the fast sodium channel is pH-dependent (lidocaine-like effect, class I_b effect) and is increased when pH drops; so when it is myocardial ischemia