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目的：探讨周围神经嵌压后病理形态改变及离子含量变化与压力的关系。方法：新西兰大白兔２０只，按压力大小分为０ｋＰａ、４ｋＰａ、８ｋＰａ、１２ｋＰａ４组。将双坐骨神经游离后从神经压迫器的孔隙内通过，持续加压１ｈ后解除压迫，术后１周取材，制作病理切片和神经单丝纤维撕梳，行组织形态学观察。ＧＧ－Ｘ原子吸收分光法测定各压力组坐骨神经内钾、钠、钙等元素的含量。结果：各压力组神经受压段和气囊两端粗神经纤维均发生不同程度的节段性脱髓鞘改变，神经的远端脱髓鞘不明显；不同压力作用下的受压神经段Ｋ＋、Ｎａ＋、Ｃａ２＋等含量均有不同变化。结论：不同压力作用下受压神经段均发生不同程度节段性脱髓鞘改变，其程度与压力成正比；受压神经组织Ｋ＋、Ｎａ＋、Ｃａ２＋浓度升高与压力高低呈正相关；离子分布平衡失调可造成神经继发性损伤
Objective: To investigate the relationship between pathological changes and ion content changes and pressure after peripheral nerve entrapment. Methods: Twenty New Zealand white rabbits were divided into 0kPa, 4kPa, 8kPa and 12kPa4 groups according to the pressure. After the sciatic nerve was free, it was passed through the pores of the nerve compressors, and the pressure was released after 1 h of continuous compression. After 1 week, the sciatic nerves were taken out for histological examination and histological observation. GG-X atomic absorption spectrophotometry was used to measure the contents of potassium, sodium, calcium and other elements in the sciatic nerve of each pressure group. Results: The nerve compression in each pressure group and the nerve fibers at both ends of the balloon occurred varying degrees of demyelination, distal nerve demyelination is not obvious; under different pressures of the compression of the nerve segment K + Na +, Ca2 + and other content have different changes. CONCLUSION: Different degrees of demyelination occur in the compressed nerve segments under different pressures, and the degree is proportional to the pressure. The increase of K +, Na + and Ca2 + concentrations in the compressed nerve tissue is positively correlated with the pressure level. The ion distribution is balanced Disorders can cause secondary neurological damage