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目的探讨职业性噪声接触对作业工人血清同型半胱氨酸(Hcy)及血脂水平的影响。方法采用整群抽样方法,选取山东省3家噪声作业工厂从事噪声作业的247名工人为接触组,以同厂非噪声作业的198名工人为对照组。采用循环酶法分别检测作业工人血清Hcy、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)水平,采用多因素Logistic回归分析作业工人高Hcy血症的影响因素。结果 3家工厂工作场所噪声8 h等效声级超标率为44.4%~50.0%。接触组男、女性工人血清Hcy水平分别高于对照组同性别工人(P<0.01),接触组女性工人HDL水平低于对照组女性工人(P<0.01);2组工人血清TG、TC和LDL分别比较,差异均无统计学意义(P>0.05)。接触组工人高Hcy血症检出率高于对照组工人(91.50%vs 56.57%,P<0.01)。从事噪声作业和性别均是导致作业工人发生高Hcy血症的影响因素(P<0.01)。噪声作业工人发生高Hcy血症的比值比(OR)是非噪声作业工人的2.78倍,男性工人发生高Hcy血症的OR是女性工人的6.21倍。结论职业性噪声接触可导致作业工人Hcy水平升高。
Objective To investigate the effects of occupational noise exposure on serum homocysteine (Hcy) and blood lipid levels in workers. Methods A cluster sampling method was used to select 247 noise-exposed workers in three noise-operated factories in Shandong Province as the exposure group and 198 workers in the non-noise-operated factory as the control group. The level of serum Hcy, triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) were detected by cyclic enzyme method, and multivariate Logistic regression Influencing factors of Hcymia. Results The noise level of 8 factories in 3 factories exceeded the standard sound level by 44.4% ~ 50.0%. The levels of Hcy in male and female workers in the exposed group were higher than those in the control group (P <0.01), while the female workers in the exposed group were lower than the female workers in the control group (P <0.01). The TG, TC and LDL There was no significant difference between the two groups (P> 0.05). The detection rate of Hcy in the exposed group was higher than that in the control group (91.50% vs 56.57%, P <0.01). Engaging in noise and sex were the influencing factors of high Hcymia in workers (P <0.01). The odds ratio (OR) for noise-induced hypertension in workers with high Hcy was 2.78 times more than that in non-noise workers, and that for male workers was 6.21 times higher than in women workers. Conclusion Occupational noise exposure may lead to an increase in Hcy levels in workers.