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目的:分析血清神经特异性烯醇化酶(NSE)和血清钙水平与新生儿缺氧缺血性脑病(HIE)的临床相关性,探讨新生儿HIE早期诊断的有效参考指标。方法:选择同期HIE新生儿62例,根据临床表现分为轻度组(n=24例)、中度组(n=20例)和重度组(n=18例),分析以上新生儿在出生第1 d、第3 d和第5 d的血清NSE和血清钙水平的动态改变与病变严重程度间的临床相关性。结果:出生第1 d血清NSE水平与病变严重程度间呈正相关性(P<0.05),血清钙水平与病变严重程度间呈负相关性(P<0.05),不同严重程度HIE新生儿间血清NSE和血清钙水平差异具有统计学意义(P<0.01,P<0.05);出生第1d与第3d、第5d的血清NSE和血清钙水平比较,差异具有统计学意义(P<0.01,P<0.05)。结论:血清NSE和血清钙水平与新生儿HIE密切相关,可反映新生儿HIE的严重程度与发展情况,两者是反映新生儿HIE诊治的有效参考指标。
OBJECTIVE: To analyze the clinical relevance of serum NSE and serum calcium levels in neonate with hypoxic-ischemic encephalopathy (HIE) and to explore effective reference indicators for the early diagnosis of neonatal HIE. Methods: Sixty-two neonates with HIE during the same period were selected and divided into mild group (n = 24), moderate group (n = 20) and severe group (n = 18) according to clinical manifestations. The clinical correlations between the dynamic changes of serum NSE and serum calcium levels on day 1, day 3 and day 5 and the severity of the disease. Results: There was a positive correlation between serum NSE levels and the severity of the disease on the first day of life (P <0.05), and the serum calcium level was negatively correlated with the severity of the disease (P <0.05). Serum NSE (P <0.01, P <0.05). There was significant difference in serum NSE and serum calcium levels between the first day, the third day and the fifth day of birth (P <0.01, P <0.05) ). Conclusion: Serum NSE and serum calcium level are closely related to neonatal HIE, which can reflect the severity and development of neonatal HIE. Both of them are effective reference indexes to reflect the diagnosis and treatment of neonatal HIE.