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目的探讨肝局灶性结节性增生的临床病理学特点。方法收集10例肝局灶性结节性增生患者的临床资料,观察该病的HE染色形态特点。结果 男性6例,女性4例,年龄16～55岁(平均34岁)。6例有特征性的中央瘢痕,由纤维结缔组织和扭曲的血管组成,并向外放射状形成纤维间隔。纤维间隔围绕无明显异型的肝细胞形成结节,结节周边肝细胞与纤维间隔内增生的小胆管上皮相互移行,周围肝组织未见结节性肝硬化。随访1～52个月,均无复发。结论肝局灶性结节性增生是肝脏良性增生性病变,组织学上应与肝结节性再生性增生、肝细胞腺瘤、高分化肝细胞肝癌进行鉴别。
Objective To investigate the clinicopathological features of focal nodular hyperplasia in liver. Methods The clinical data of 10 patients with focal nodular hyperplasia were collected and their morphological characteristics of HE staining were observed. Results There were 6 males and 4 females, aged from 16 to 55 years (average 34 years). Six cases characterized by central scar, composed of fibrous connective tissue and twisted blood vessels, and outward radial formation of fibrous septa. Fibrous septa formed around the liver cells without obvious heterotrophic nodules, peripheral nodules and small bile duct epithelial hyperplasia within the fibrous interplantadenia migration, no nodular cirrhosis around the liver tissue. Follow-up 1 ~ 52 months, no recurrence. Conclusion Focal nodular hyperplasia of liver is a benign hyperplastic lesion of liver, which should be differentiated from hepatic nodular regenerative hyperplasia, hepatocellular adenoma and highly differentiated hepatocellular carcinoma.