酮洛芬是一种α-芳基丙酸非甾体抗炎药物。右酮洛芬(dexketoprofen)是用拆分方法得到的酮洛芬的光学异构体,其作用几乎为同剂量酮洛芬的2倍,镇痛作用强,起效迅速,不良反应少。目前我国处于新药研制阶段。本实验采用手性固定相HPLC法测定右酮洛芬含量,方法简便,结果准确。1 仪器与试药 Ketoprofen is an alpha-aryl propionate NSAID. Dexketoprofen is an optical isomer of ketoprofen obtained by the resolution method. Its effect is almost twice as high as that of ketoprofen, with strong analgesic effect, rapid onset of action and few adverse reactions. At present, China is in the stage of developing new drugs. In this study, determination of dexketoprofen by HPLC with chiral stationary phase method, the method is simple and accurate. 1 instruments and reagents