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目的对艾普拉唑肠溶片治疗十二指肠溃疡的疗效和安全性进行分析。方法选择经胃镜检查证实为活动性十二指肠溃疡并按医嘱服用艾普拉唑肠溶片(1次5 mg,1日1次,疗程4周)的患者。对艾普拉唑肠溶片治疗十二指肠溃疡的4周疗效和安全性进行分析。结果纳入分析的十二指肠溃疡患者共902例。4周溃疡愈合率84.15%、痊愈率49.45%;4周综合症状改善显效率95.77%、有效率97.66%。共发生不良反应21例,不良反应发生率2.33%,不良反应均为轻中度,且没有明显时间集中现象;不同年龄及性别患者间的疗效和不良反应发生率相似。结论艾普拉唑肠溶片能显著改善十二指肠溃疡患者临床症状、促进溃疡愈合,安全性良好。
Objective To analyze the efficacy and safety of ilaprazole enteric-coated tablets in the treatment of duodenal ulcer. Methods Selected patients with active duodenal ulcer confirmed by gastroscopy and taking ilaprazole enteric-coated tablets (5 mg once daily, once daily for 4 weeks) according to doctor’s orders. The efficacy and safety of ilaprazole enteric-coated tablets in the treatment of duodenal ulcer for 4 weeks were analyzed. Results A total of 902 patients with duodenal ulcer were included in the analysis. The healing rate of ulcer in four weeks was 84.15% and the cure rate was 49.45%. The effective rate of four weeks improvement was 95.77% and the effective rate was 97.66%. A total of 21 cases of adverse reactions occurred, the incidence of adverse reactions 2.33%, adverse reactions were mild to moderate, and there is no obvious time concentration; different age and gender in patients with similar efficacy and adverse reactions. Conclusion Ipraconazole enteric-coated tablets can significantly improve the clinical symptoms of patients with duodenal ulcer, promote ulcer healing, good safety.