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目的 探讨 β4 整合素在前列腺各组织中的表达及意义。方法 将 10 0例诊断明确的前列腺标本分为五组 ,即正常组 (NP)、良性前列腺增生组 (BPH)、高级别上皮内瘤组 (HPIN)、偶发癌组 (PIC)及前列腺癌组 (PC) ,每组 2 0例。应用免疫组化SP法检测 β4 整合素在以上五组标本中的表达情况。结果 β4 整合素在NP、BPH、HPIN、PIC及PC组织中的表达是逐渐降低的 ,BPH组表达明显强于HPIN组 ,其差异有显著意义 (P <0 .0 5 ) ,HPIN组和PIC组的表达无显著差别 (P >0 .0 5 )。结论 β4 整合素与前列腺癌发生、发展密切相关。
Objective To investigate the expression and significance of β4 integrin in various tissues of prostate. Methods One hundred and ten cases of diagnosed prostate were divided into five groups: normal group (NP), benign prostatic hyperplasia group (BPH), high grade intraepithelial neoplasia group (HPIN), incidental cancer group (PIC) and prostate cancer group (PC), 20 cases each. The immunohistochemical SP method was used to detect the expression of β4 integrin in the above five groups of specimens. Results The expression of β4 integrin in the tissues of NP, BPH, HPIN, PIC and PC was gradually decreased, and the expression of β4 integrin in HPH group was significantly higher than that in HPIN group (P <0.05). HPIN group and PIC There was no significant difference between the two groups (P> 0.05). Conclusion β4 integrin is closely related to the occurrence and development of prostate cancer.