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目的探讨椎体成形术联合止痛药物治疗晚期骨转移癌患者癌痛的临床疗效。方法选择2012年1—12月晚期肿瘤脊柱骨转移患者12例作为研究对象,采用椎体成形术联合止痛药物治疗,术前、术后1周、术后1月、术后3月分别采用视觉模拟评分法(VAS)评估患者的疼痛状况,采用Karnofsky功能状态评分标准(KPS)量表评估患者的功能状态,采用Barthel量表评估患者基本日常生活活动能力(ADL),并进行对比分析。结果 VAS评分术后明显下降,术后1周、术后1月维持稳定水平,术后3月出现上升趋势,与术前比较差异均有统计意义(P<0.05);KPS评分术后1周、术后1月、术后3月与术前比较差异均无统计意义(P>0.05);Barthel指数在术后1周、术后1月明显上升(P<0.05),术后3月低于术前(P<0.05)。术后1周总体疼痛改善率为61.15%,术后1月为57.96%,术后3月为44.59%。结论椎体成形术联合止痛药物可以缓解癌痛,短期内提高患者ADL,但不能改善患者的功能状态。
Objective To investigate the clinical efficacy of vertebroplasty combined with analgesic drugs in the treatment of cancer patients with advanced bone metastases. Methods Twelve patients with spine bone metastasis from January to December in 2012 were selected as the study objects. The patients were treated with vertebroplasty combined with analgesic drugs. One week before operation, one week after operation, one month after operation, and three months after operation, The patients were assessed for pain by simulated score (VAS). Functional status was assessed using the Karnofsky Functional Status Scale (KPS) scale. Barthel’s scale was used to assess the patient’s basic daily living activity (ADL). Results The VAS score decreased significantly postoperatively, and remained stable at 1 week and 1 month after operation. The VAS score showed an upward trend at 3 months after operation, which was statistically different from that before operation (P <0.05) (P> 0.05). The Barthel index increased significantly at 1 week after operation and at 1 month after operation (P <0.05), while at 3 months after operation, there was no significant difference between January and March after operation Preoperatively (P <0.05). The improvement rate of total pain in one week after operation was 61.15%, 57.96% in January and 44.59% in March. Conclusions Vertebroplasty combined with analgesic drugs can relieve cancer pain and improve ADL in short term, but can not improve the functional status of patients.