脑卒中是临床上难以攻克的一类神经系统疾病.以间充质干细胞(MSC)为基础的细胞移植为广大脑卒中患者健康的恢复带来了希望,但目前对MSC用于脑卒中治疗的研究不够透彻,仍然面临一些问题.该文旨在从MSC的组织来源、制备流程、时间窗、移植途径、预处理、联合用药、示踪方法等角度,对其在脑卒中治疗中面临的一些问题进行综述,以期为科研和临床应用提供指导.“,”Stroke is a neurological disease which is difficult to conquer clinically .Cell transplantation based on mesenchymal stem cells(MSCs) provides hope for the healthy recovery of stroke patients , but our study of MSCs for stroke therapy is not thorough enough and still faces some problems .The aim of this paper is to summarize the problems with MSCs in the treatment of stroke from the perspectives of tissue source , preparation process, time window, transplantation pathway , pretreatment , combined medication and tracer method , in order to provide guidance for scientific research and clinical application.