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新生儿皮质醇分泌缺乏正常生理节奏,且肾上腺皮质功能与胎龄相关。肾上腺皮质功能低下与新生儿慢性肺疾病(CLD)及其预后有一定关系,并可能对新生儿死亡率有影响。其机制尚不明确,可能是由于促炎症反应和抗炎症反应机制的不平衡引起,促炎症细胞因子大量增加使HPA轴调节受到抑制。目前肾上腺皮质功能不全没有统一的诊断标准。糖皮质激素作为抗炎剂,其应用有较好疗效,但是应小剂量、短疗程,并且应注意糖皮质激素的不良反应。
Neonatal cortisol secretion lacks normal circadian rhythm, and adrenocortical function is associated with gestational age. Adrenal insufficiency and neonatal chronic lung disease (CLD) and its prognosis have a certain relationship, and may have an impact on neonatal mortality. The mechanism is not clear, probably due to the imbalance of the proinflammatory and anti-inflammatory response mechanisms. A large increase in proinflammatory cytokines inhibits HPA axis modulation. Currently there is no uniform diagnostic criteria for adrenal insufficiency. Glucocorticoids as anti-inflammatory agents, its application has a good effect, but should be low-dose, short course, and should pay attention to the adverse effects of glucocorticoid.