六亚甲基二乙酰胺(Hexamethylene Bisacetamide,HMBA)是一小分子量平面极性化合物,作为分化诱导剂,它能诱导鼠红白血病细胞(MELC)合成血红蛋白,诱导人早幼粒白血病细胞(HL-60)成为成热粒细胞,诱导多种实体癌细胞分化.本实验用HMBA对人涎腺粘液表皮样癌细胞系MEC-1细胞进行体外诱导,经细胞生长动力学、细胞形态学、DNA含量及染色体等观察,结果显示,在HMBA作用下MEC-1细胞有向成热细胞分化的趋势. Hexamethylene Bisacetamide (HMBA) is a low molecular weight planar polar compound that acts as a differentiation-inducing agent and induces murine erythroleukemia cells (MELC) to synthesize hemoglobin and induces human promyelocytic leukemia cells (HL- 60) To become a granulocyte, to induce differentiation of various solid cancer cells. In this experiment, HMBA was used to induce human salivary mucoepidermoid carcinoma cell line MEC-1 cells in vitro, and the cell growth kinetics, cell morphology, and DNA content were determined. And chromosomes and other observations, the results show that under the influence of HMBA MEC-1 cells have a tendency to differentiate into heat-producing cells.