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目的:探讨阿托伐他汀对急性ST段抬高型心肌梗死(STEMI)患者梗死相关血管(IRA)再通的影响。方法:2007-05-2008-01,连续入选116例急性ST段抬高心肌梗死患者。年龄29～85岁,随机分为对照组和早期阿托伐他汀干预组(干预组,行急诊冠状动脉造影及介入治疗之前,口服80mg),随后行急诊冠状动脉造影,评价冠状动脉血管病变情况,冠状动脉IRA再通率和心肌梗死溶栓治疗临床试验(TIMI)血流情况。结果:60例对照组和56例干预组基础情况,包括性别、年龄、高血压、糖尿病、血脂、梗死前心绞痛病史等差异无统计学意义(P>0.05),2组间IRA和心肌梗死发病时间无差异(P>0.05)。IRA自发再通比例,在干预组明显高于对照组,前向TIMI血流亦存在显著差异(P=0.012)。结论:急性STEMI患者早期应用阿托伐他汀可提高IRA自发再通率及改善前向TIMI血流。
Objective: To investigate the effect of atorvastatin on recanalization of infarct-related blood vessels (IRA) in patients with acute ST-segment elevation myocardial infarction (STEMI). METHODS: From May 2007 to January 2008, 116 consecutive patients with acute ST-segment elevation myocardial infarction were enrolled. Aged 29-85 years old, were randomly divided into control group and early atorvastatin intervention group (intervention group, emergency coronary angiography and intervention before oral administration of 80mg), followed by emergency coronary angiography to assess coronary artery disease , Coronary IRA recanalization and myocardial infarction thrombolytic therapy (TIMI) blood flow. Results: There was no significant difference in the basic conditions of 60 control subjects and 56 interventions including gender, age, hypertension, diabetes mellitus, blood lipids, history of pre-infarction angina pectoris (P> 0.05), IRA and myocardial infarction No difference in time (P> 0.05). IRA spontaneous recanalization ratio in the intervention group was significantly higher than the control group, the anterior TIMI blood flow there are also significant differences (P = 0.012). Conclusion: Early use of atorvastatin in patients with acute STEMI can improve the spontaneous recanalization rate and improve the anterior TIMI flow.