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目的观察抗菌素与益生菌制剂序贯治疗腹泻型肠易激综合征(D-IBS)患者的疗效。方法将86例患者分为3组,A组给予抗菌素、匹维溴铵、复方谷氨酰胺肠溶胶囊治疗1周,继之以双歧三联活菌胶囊、匹维溴铵、复方谷氨酰胺肠溶胶囊治疗7周;B组进行菌剂治疗,应用双歧三联活菌胶囊、匹维溴铵、复方谷氨酰胺肠溶胶囊治疗8周;C组进行一般治疗,应用匹维溴铵、复方谷氨酰胺肠溶胶囊治疗8周。记录治疗前后各组消化道症状评分。结果各组治疗中及治疗后较入组时腹痛持续时间明显缩短,腹痛频率明显下降,大便性状异常比例和排便异常比例下降。治疗前3组消化道评分均较高,治疗1周后开始下降,第4周时症状评分值下降较明显,组间比较差异有统计学意义,并维持到停药4周,A组优于B、C组。结论序贯治疗、菌剂治疗和一般治疗组均能缓解D-IBS患者的下消化道症状,但序贯治疗组缓解作用更明显,且维持缓解的时间更长。
Objective To observe the efficacy of sequential antibiotic and probiotic preparations in treating diarrhea-predominant irritable bowel syndrome (D-IBS). Methods Eighty-six patients were divided into three groups. Group A was treated with antibiotics, pinaverium bromide and compound glutamine enteric-coated capsules for one week, followed by live bifidobacterium capsule, pinaverium bromide, compound glutamine Enteric-coated capsules for 7 weeks; group B for the treatment of bacteria, the application of bifid triple viable capsules, verapamil, compound glutamine enteric-coated capsules for 8 weeks; C group for general treatment, Compound glutamine enteric-coated capsules for 8 weeks. Record before and after treatment of gastrointestinal symptoms score. Results Compared with the control group, the duration of abdominal pain, the frequency of abdominal pain and the proportion of defecation abnormalities in defecation decreased significantly. The scores of digestive tract in the three groups before treatment were higher than those in the control group, decreased after one week of treatment, and decreased significantly in the fourth week. There was a significant difference between the two groups B, C group. Conclusions Sequential treatment, mycotic therapy and general treatment group can relieve the symptoms of lower gastrointestinal tract in patients with D-IBS. However, the sequential therapy group is more effective in relieving the symptoms and has longer remission.