川崎病(Kawasaki disease,KD)又称皮肤黏膜淋巴结综合征,是一种以全身血管炎为主要病理改变的急性发热出疹性疾病,发病机制尚不完全清楚。由于本病可引发严重的心血管病变,从而引起人们的重视。内皮微粒(endothelial microparticles,EMP)是内皮细胞在激活或凋亡状态下所释放的微小囊泡状物质。近年来实验证明EMP在炎症、免疫、凝血[1]及血管功能等方面[2]均有一定的影响,并与心 Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome, is an acute febrile and rash disease characterized by systemic vasculitis. The pathogenesis is not yet fully understood. Because of this disease can cause serious cardiovascular disease, which attracted people’s attention. Endothelial microparticles (EMPs) are tiny vesicular substances released by endothelial cells during activation or apoptosis. In recent years, experiments show that EMP in inflammation, immune, clotting [1] and vascular function [2] have a certain impact, and heart