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目的:多瑞吉是强阿片类镇痛药芬太尼的控释透皮贴剂,具有使用方便,镇痛效果稳定持久和不良反应较轻等优点。本项研究目的是观察大样本多瑞吉的疗效和不良反应。方法:统计了上市后3791例患者(男性2494例,女性1297例;年龄6～94岁,平均年龄56.84岁)的临床资料。结果:无论轻、中、重度疼痛均缓解良好,疗效和剂量相关,起效时间为3～6天,在6、9、15、30天时镇痛作用持续而稳定。对患者用药前后生活质量进行统计,治疗后有明显提高,说明多瑞吉的镇痛给患者带来了实际的裨益。不良反应中头晕、恶心、便秘和嗜睡比较常见,少数患者局部有轻度过敏。呼吸抑制为0.32%(12/3791),未发现精神依赖和其他罕见不良反应。结论:多瑞吉大样本观察疗效稳定,不良反应相对较轻微。
OBJECTIVE: Doric is a controlled-release transdermal patch of fentanyl, an opioid analgesic. It has the advantages of convenient use, stable and long-lasting analgesic effect, and mild adverse reactions. The purpose of this study was to observe the efficacy and adverse reactions of a large sample of Doric. Methods: The clinical data of 3791 patients (2494 males and 1297 females; aged 6 to 94 years with a mean age of 56.84 years) after the market were collected. Results: No matter mild, moderate or severe pain were relieved. The curative effect was dose-dependent. The onset time was 3 to 6 days. The analgesic effect was steady and continued at 6, 9, 15 and 30 days. The quality of life of patients before and after treatment statistics, significantly improved after treatment, indicating that Du Ruiji pain relief to patients with real benefits. Adverse reactions in dizziness, nausea, constipation and drowsiness are more common, a small number of patients with mild allergies. Respiratory depression was 0.32% (12/3791), no psychic dependence and other rare adverse reactions were found. Conclusion: The results of a large sample of Doric are stable and the adverse reactions are relatively mild.