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目的:对比观察急性、慢性中心性浆液性脉络膜视网膜病变（CSC）患眼脉络膜毛细血管层血流密度及脉络膜中大血管容积（CVV）变化。方法:横断面观察性临床研究。2019年5月至2020年10月于四川大学华西医院眼科确诊为CSC的64例患者64只眼（CSC组）及同期年龄、性别匹配的健康志愿者64名64只眼（对照组）纳入研究。CSC组64例64只眼中，急性、慢性CSC分别为34例34只眼和30例30只眼，并据此再分为急性CSC组、慢性CSC组。CSC组、对照组受检者年龄（n t=-0.041 ）、性别构成比（n χ2=0.191）比较，差异无统计学意义（n P>0.05 ）。急性CSC组、慢性CSC组患者年龄（n t=-1.872）、性别构成比（n χ2=8.778）比较，差异有统计学意义（n P0.05). There were statistically significant differences in age (n t=-1.872) and sex composition ratio (n χ2=8.778) between acute CSC group and chronic CSC group(n P<0.05). Swept source optical coherence tomography angiography (SS-OCTA) was performed using VG200D. The scanning mode was 512×512 and scannig range was 12 mm × 12 mm. The choriocapillaris flow density of the 3 mm, 6 mm, 12 mm circular area and 1-3 mm ring, 3-6 mm ring, and 6-12 mm ring, and the CVV of the of the 3 mm, 6 mm, 12 mm circular area was automatically generated by the built-in software (v1.28.6). The age, choriocapillaris flow density and CVV were compared between two groups using independent samplen t test.n Results:Compared with the control group, the choriocapillaris flow density decreased in the CSC group, and there were statistically significant differences in the 3 mm, 6 mm circular area (n t=-7.210, -4.040; n P<0.001). There were statistically significant differences between CSC group and control group in the 3 mm, 6 mm, 12 mm circular area (n t=1.460, 12.270, 11.250; n P<0.05). Compared with the acute CSC group, the choriocapillaris flow density decreased in the chronic CSC group, and there were statistically significant differences (n P0.05).n Conclusion:Compared with acute CSC, chronic CSC exhibits significant decreased choriocapillaris flow density and no change in CVV.