自从七十年代顺铂(DDP)问世,已广泛用于临床且证明对辜丸、卵巢、肺、头颈癌等有明显疗效,但因其严重的肾毒性和严重的呕吐等毒副作用限制了其在临床上的使用。为了寻找高效低毒的铂合物,近十年来合成了一千多种铂化合物,发现一些肾毒性小的第二代铂合物,其中较好的有卡铂(碳 Since the advent of cisplatin (DDP) in the 1970s, it has been widely used in clinical practice and has proved to be effective in treating ecstasy, ovary, lung, head and neck cancer, etc. However, due to its severe nephrotoxicity and severe vomiting, it has limited its toxic and side effects. Clinical use. In order to find highly effective and low-toxicity platinum compounds, more than 1,000 platinum compounds have been synthesized in the past decade. Some second-generation platinum compounds with low nephrotoxicity have been found, among which carboplatin (carbon) is preferred.