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胃癌是一种消化系统恶性肿瘤,在我国恶性肿瘤的发病率中位居第二位~([1])。由于胃癌没有典型的临床症状,很多患者确诊时已是晚期,只能采取放化疗,而放化疗较强的毒副作用对患者的身体造成严重的影响~([2,3])。目前寻找毒副作用小、疗效好的抗肿瘤药物是当务之急。研究显示,三氧化二砷(As2O3)对卵巢癌、肺癌、骨肉瘤等多种实体肿瘤具有抑制作用,主要是通过改变肿瘤细胞的信号传导、基因的表达等来诱
Gastric cancer is a malignant tumor of the digestive system, which ranks the second highest in the incidence of malignant tumors in China ([1]). Because there is no typical clinical symptoms of gastric cancer, many patients have been diagnosed late, can only take radiotherapy and chemotherapy, and strong side effects of radiotherapy and chemotherapy on patients with severe adverse effects on the body (2,3). Currently looking for small side effects, effective anti-cancer drugs is a top priority. Studies have shown that arsenic trioxide (As2O3) on ovarian cancer, lung cancer, osteosarcoma and other solid tumors have an inhibitory effect, mainly by changing the signal transduction of tumor cells, gene expression, etc. to lure