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采用HA和DA方案交替化疗,对32例经全反式维甲酸诱导分化治疗达完全缓解的急性早幼粒细胞白血病(APL)病人,作继续治疗。随访14~114个月,中位缓解期39个月,中位生存期44个月;其中16例持续完全缓解36~96个月,8例生存5年以上;13例复发(40.6%)。分析认为,HA、DA交替化疗作为APL缓解后的继续治疗,生存期长,复发率低,是一种比较合理的方案。
Using alternating HA and DA chemotherapy, 32 patients with acute promyelocytic leukemia (APL) who had achieved complete remission with all-trans retinoic acid induced differentiation were treated for continued treatment. Follow-up was 14 to 114 months. The median remission period was 39 months. The median survival period was 44 months. Among them, 16 cases sustained complete remission 36-96 months, 8 cases survived more than 5 years; 13 cases relapsed (40.6%) ). According to the analysis, alternate chemotherapy with HA and DA as a continuation therapy after APL remission has a long survival period and a low recurrence rate. It is a relatively reasonable plan.