自Kern(1921)首次报道屋尘浸液可诱导哮喘病患者皮肤速发型变态反应以来,屋尘被认为是重要的哮喘诱发因素之一。此后,Tuft(1949)报道了许多例特应性皮炎患者均对屋尘浸液产生速发型皮肤变态反应,证实屋尘含有某种特应性变应原,但其具体来源尚不清楚[1]。直至1964年,Voorhorst等 House dust has been identified as one of the most important asthma triggers since Kern (1921) first reported that house dust immersion induced skin-induced hay -burn allergies in asthmatics. Since then, Tuft (1949) reported that many patients with atopic dermatitis developed rapid-onset skin allergy to house dust infiltrates, confirming that house dust contains some atopic allergens but its exact origin is not clear [1 ]. Until 1964, Voorhorst et al