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通过复制家兔动脉粥样硬化(As)模型,初步探讨实验前、后家兔 LPL 活性及其与病理变化的关系。同时检测了血脂水平。实验组 PH—LPL 活性于实验后4周开始降低,尤以13周为明显(P<0.01);13周时成活的11只兔中,有8只主动脉呈现不同程度的病变(霞度4只,中度1只,轻度3只),且与 PH—LPL 活性呈负相关(r_s=-0.685,P<0.05)。PH—LPL 活性差值(与实验前);重度>0.965mmol/L/h,中、轻度0.820～0.540mmol/L/h,<0.300mmol/L/h 为As 病变较难形成,因此,PH—LPL 活性在估计主动脉病变的有无和程度上有一定意义。
By replicating atherosclerosis (As) model in rabbits, the activity of LPL in rabbits before and after the experiment and its relationship with pathological changes were preliminarily explored. At the same time, blood lipid levels were measured. The activity of PH-LPL in the experimental group began to decrease at 4 weeks after the experiment, especially at 13 weeks (P<0.01); of the 11 rabbits that survived at 13 weeks, 8 of the aorta showed varying degrees of lesions (Xia 4 Only 1 was moderate, 3 was mild, and negatively correlated with PH-LPL activity (r_s=-0.685, P<0.05). PH-LPL activity difference (before experiment); severity >0.965 mmol/L/h, moderate to mild 0.820 to 0.540 mmol/L/h, <0.300 mmol/L/h is more difficult to form As lesions, therefore, PH-LPL activity has a certain significance in estimating the presence and extent of aortic lesions.