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目的采用Meta分析方法评价双歧杆菌三联活菌制剂治疗轮状病毒肠炎的临床疗效。方法计算机检索中国知网、万方、维普、Pubmed、Embase和Web of Science数据库,检索时限均从建库至2015年12月,收集国内外应用双歧杆菌三联活菌制剂治疗轮状病毒肠炎的所有随机对照试验(RCT)和前瞻性非随机对照试验(non-RCT)。按照纳入与排除标准选择文献、提取资料和评价纳入研究的方法学质量后,采用Cochrane协作网提供的Rev Man 5.2软件于2016-02-05进行Meta分析。结果检索文献无RCT研究,纳入21篇包含23个前瞻性non-RCT研究文献,合计3388例患儿,其中治疗组(对照组常规治疗+双歧杆菌三联活菌胶囊或散剂)1804例,对照组1584例。Meta分析结果显示:治疗组有效率高于对照组[OR=4.59,95%CI(3.69,5.70),P<0.01];治疗组止泻所用时间少于对照组[平均差(MD)=-1.39,95%CI(-2.24,-0.53),P=0.001];治疗组总治疗时间少于对照组[MD=-1.32,95%CI(-2.19,-0.45),P=0.003]。结论 Meta分析评价现有文献认为,双歧杆菌三联活菌胶囊或散剂与常规治疗措施联用可提高轮状病毒肠炎的总体疗效,并有效缩短止泻时间和总治疗时间。
Objective To evaluate the clinical efficacy of Bifidobacterium triple viable bacteria in the treatment of rotavirus enteritis by Meta analysis. Methods The databases of CNKI, Wanfang, Weipu, Pubmed, Embase and Web of Science were searched by computer, and the search time was from the database to December 2015. The domestic and international application of Bifidobacterium triple viable agents for the treatment of rotavirus enteritis All randomized controlled trials (RCTs) and prospective non-RCTs (non-RCTs). Meta-analysis was performed on 2016-02-05 using Rev Man 5.2 software provided by the Cochrane Collaboration after selecting the literature on inclusion and exclusion criteria, extracting data, and evaluating the quality of the included studies. Results There were no RCTs in the retrieved articles, including 21 articles containing 23 prospective non-RCT studies, with a total of 3388 children, of whom 1804 in the treatment group (routine treatment + Bifidobacterium triple viable capsule or powder) Group 1584 cases. Meta analysis showed that the effective rate of the treatment group was higher than that of the control group [OR = 4.59,95% CI (3.69,5.70), P <0.01]; the treatment group had less time to stop diarrhea than the control group [mean difference (MD) 1.39, 95% CI (-2.24, -0.53), P = 0.001]. The total treatment time in the treatment group was less than that in the control group [MD = -1.32,95% CI (-2.19, -0.45), P = 0.003]. Conclusion Meta analysis of existing literature that the Bifidobacterium triple viable capsules or powder combined with conventional treatment can increase the overall efficacy of rotavirus enteritis and effectively reduce the diarrhea and total treatment time.