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目的:评价新型的生物可降解聚合物雷帕霉素靶向洗脱支架—Firehawk在小型猪冠状动脉模型预防支架内狭窄的疗效。方法:将Firehawk支架(Firehawk组,n=10)和采用永久聚合物涂层雷帕霉素洗脱支架Firebird 2(Firebird 2组,n=8)置入健康小型猪冠状动脉。术后4周时测定两组支架血管段的平均内膜厚度、新生内膜面积、面积狭窄百分比等参数,以比较其内膜增生的情况。结果:术后4周,Firehawk组和Firebird 2组平均内膜厚度分别为(0.15±0.10)mm和(0.14±0.06)mm,新生内膜面积分别为(1.12±0.57)mm2和(1.04±0.36)mm2,面积狭窄百分比分别为(24.58±14.85)%和(26.80±10.64)%,差异均无统计学意义(P均>0.05)。两组均无支架内狭窄发生。结论:Firehawk支架可有效抑制支架置入后4周时的内膜增生,预防冠状动脉实验性支架内狭窄,效果与传统的永久聚合物涂层药物洗脱支架相当。长期效果有待进一步观察。
OBJECTIVE: To evaluate the efficacy of a novel biodegradable polymer rapamycin-targeted eluting stent, Firehawk, in the prevention of stenosis in mini-swine coronary arteries. Methods: Firehawk scaffolds (Firehawk group, n = 10) and Firebird 2 (Firebird group 2, n = 8) with a permanent polymer-coated rapamycin eluting stent were placed into healthy miniature pig coronary arteries. At 4 weeks after operation, the intima-media thickness, neointimal area and percentage of stenosis area of the two groups were measured to compare the intimal hyperplasia. Results: At 4 weeks after operation, the mean intimal thicknesses of Firehawk group and Firebird group were (0.15 ± 0.10) mm and (0.14 ± 0.06) mm respectively, and the neointimal area were (1.12 ± 0.57) mm2 and (1.04 ± 0.36 ) mm2, the percentages of stenosis were (24.58 ± 14.85)% and (26.80 ± 10.64)%, respectively, with no significant difference (all P> 0.05). No stent stenosis occurred in either group. Conclusion: The Firehawk stent can effectively inhibit intimal hyperplasia at 4 weeks after stent implantation and prevent coronary stent stenosis, which is equivalent to the traditional permanent polymer-coated drug-eluting stent. Long-term results need to be further observed.