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采用国产单克隆抗体酶标试剂盒(McAb—ELISA)对广东某地区无乙肝症状的298人作了血清前S_2蛋白及抗前S_2检测,同时检测各项乙型肝炎病毒血清学标志(HBVM)及肝功能。全部检测对象肝功能正常。前S_2阳性率7.72％。抗前S_2阳性率5.70％。前者与HBsAg及其它乙肝病毒复制标志(HBcAg、PHSA-R、HBcAg、抗-HBcIgM及HBVDNA)有平行关系,后者则与抗HBs有平行关系。结果提示前S_2可作为一项敏感的HBV复制及传染性的指标,抗前S_2是一项乙肝感染的恢复标志,二者有重要的流行病学与临床意义,检测证实人群中存在相当数量的HBV携带者和隐性感染者。
A total of 298 hepatitis B-free patients in a certain area of Guangdong Province were tested for anti-S 2 and anti-S 2 by using McAb-ELISA kit. HBVM, And liver function. All subjects had normal liver function. Pre-S 2 positive rate of 7.72%. Pre-anti-S 2 positive rate of 5.70%. The former has a parallel relationship with HBsAg and other hepatitis B virus replication markers (HBcAg, PHSA-R, HBcAg, anti-HBcIgM and HBVDNA), while the latter has parallel relationship with anti-HBs. The results suggest that before S 2 can be used as a sensitive marker of HBV replication and infectivity, anti-pre-S 2 is a recovery sign of hepatitis B infection, both have important epidemiological and clinical significance, the test confirmed that the population there is a considerable number of HBV carriers and latent infection.