目的评价１３１ＩＢＳＡ作为胃固体排空标记物的稳定性和临床应用价值．方法以１３１ＩＢＳＡ和９９ｍＴｃＤＴＰＡ分别作为混合餐固、液体食物的标记物，检测３５例慢性胃炎患者和１０名健康志愿者的胃排空，其中２例受检者１周内进一步用９９ｍＴｃＳＣ复查固体排空，比较两次固体排空过程的相关性．在体外对上述３种放射性标记物在胃液、１ｍｏｌ／ＬＮａＣｌ和０１ｍｏｌ／ＬＨＣｌ溶液中消化２ｈ，检测其稳定性．结果１３１ＩＢＳＡ和９９ｍＴｃＳＣ标记的固体食物经消化后的脱标率分别＜２８７％和４６３％，９９ｍＴｃＤＴＰＡ吸附于固相的吸附率＜８３６％．固、液体排空曲线明显不同，固体排空有明显的延迟期，半排空时间较长，慢性胃炎患者固、液体排空时间均较正常对照组延长，两种固体标记物的排空曲线相似，相关性为ｒ＝０９８９（Ｐ＜００１），前、后两次排空相比，最大差值为９２％，最小差值仅为０８％．结论１３１ＩＢＳＡ固体标记物稳定性较好，可用于临床胃排空的检测． Objective To evaluate the stability and clinical value of 131IBSA as a gastric emptying marker. Methods 131IBSA and 99mTcDTPA were respectively used as a solid food and liquid food marker to detect gastric emptying in 35 patients with chronic gastritis and 10 healthy volunteers. Two patients were further treated with 99mTc  SC review of solid emptying, comparing the two solid emptying process correlation. The above three radioactive markers were digested in gastric juice, 1 mol / L NaCl and 0.1 mol / L HCl for 2 h in vitro, and their stability was tested. Results The decolorization rates of 131IBSA and 99mTcSC labeled solid food were <287% and 463%, respectively. The adsorption rate of 99mTcDTPA to the solid phase was <836%. Solid and liquid evacuation curves were significantly different, there was a clear delay of solid emptying, half-emptying a long time, chronic gastritis patients with liquid and liquid emptying time than the normal control group, the emptying curve of two solid markers Similarly, the correlation was r = 0989 (P <001). The maximum difference was 92% and the minimum difference was only 08% when compared with the two emptyings before and after emptying. Conclusion 131I BSA solid marker stability is good, can be used for clinical gastric emptying detection.