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目的对氯硝西泮与丙咪嗪治疗儿童社交恐怖症的疗效及不良反应比较。方法儿童社交恐怖症36例(男15例,女21例,年龄12.23±2.30岁,病程2.13±0.84年),采用氯硝西泮1~4mg/d.po.治疗8周。另外,采用丙咪嗪治疗同类病人32例(男性14例,女性18例,年龄12.56±2.53岁,病程2.29±0.91年),用量25~75mg/d,po.治疗8周。结果氯硝西泮组显效率为56%,总有效率为81%,丙咪嗪显效率为50%,总有效率75%,两组疗效差异无显著意义(P>0.05),氯硝西泮组不良反应较丙咪嗪少。结论氯硝西泮对儿童社交恐怖症有肯定的治疗作用,近、远期疗效较好,且不良反应少。
AIM To compare the efficacy and side effects of clonazepam and imipramine in treating children with phobia. Methods 36 cases of children with social phobia (15 males and 21 females, age 12.23 ± 2.30 years, duration of 2.13 ± 0.84 years), the use of clonazepam 1 ~ 4mg / d.po for 8 weeks. In addition, imipramine treatment of 32 patients (14 males and 18 females, aged 12.56 ± 2.53 years, duration of 2.29 ± 0.91 years), the amount of 25 ~ 75mg / d, po for 8 weeks. Results The effective rate of clonazepam group was 56%, the total effective rate was 81%, imipramine was 50%, the total effective rate was 75%, there was no significant difference between the two groups (P> 0.05) Pan adverse reactions than imipramine less. Conclusion Clonazepam has a positive therapeutic effect on children with phobia, with good short-term and long-term effects and few adverse reactions.