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目的探讨肾特异性钙黏附蛋白(Ksp-cadherin)、β-链蛋白(β-catenin)和生存素在肾透明细胞癌(RCCC)中的表达及其相关性。方法免疫组化SP法检测73例RCCC组织标本中Kspcadherin、β-catenin和生存素的表达,分析其相关性。结果随着病理分级和临床分期的增高,β-catenin胞质和生存素阳性表达率升高(P<0.01),而β-catenin胞膜阳性表达率下降(P<0.05)。Ksp-cadherin表达在不同的病理分级和临床分期中无统计学差异(P>0.05)。β-Catenin胞质表达与生存素表达呈正相关性(r=0.475,P<0.05),β-catenin胞膜表达与生存素表达呈负相关性(r=-0.390,P<0.05),β-catenin胞质表达与β-catenin胞膜表达呈负相关性(r=-0.540,P<0.01)。Ksp-cadherin表达与β-catenin、生存素表达均无相关性。结论β-Catenin和生存素可作为预测RCCC患者生物学行为和预后的重要指标。
Objective To investigate the expression of renal-specific cadherin, β-catenin and survivin in renal clear cell carcinoma (RCCC) and their correlation. Methods The expression of Kspcadherin, β-catenin and survivin in 73 specimens of RCCC were detected by immunohistochemical SP method. The correlation was analyzed. Results The positive rate of β-catenin cytoplasm and survivin increased (P <0.01) and the positive rate of β-catenin decreased (P <0.05) with the increase of pathological grade and clinical stage. Ksp-cadherin expression in different pathological grade and clinical stage no significant difference (P> 0.05). The cytoplasmic expression of β-Catenin was positively correlated with the expression of survivin (r = 0.475, P <0.05). The expression of β-catenin was negatively correlated with the expression of survivin (r = -0.390, The cytoplasmic expression of catenin was negatively correlated with the expression of β-catenin (r = -0.540, P <0.01). There was no correlation between Ksp-cadherin expression and β-catenin, survivin expression. Conclusion β-Catenin and survivin can be used as predictors of biological behavior and prognosis in patients with RCCC.