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目的:分析并评价细胞凋亡抑制因子生存素、活素及细胞黏附分子CD44v6蛋白在宫颈癌中的表达及临床意义。方法:选取68例宫颈癌患者的宫颈标本、69例宫颈上皮内瘤变患者的宫颈标本和80例正常宫颈组织标本,采用免疫组织化学方法检测生存素、活素和CD44v6蛋白的表达水平。结果:宫颈癌患者的生存素、活素和CD44v6蛋白的阳性表达率最高,宫颈上皮内瘤变患者次之,正常宫颈组织表达量最低,三组比较差异有统计学意义(均P<0.01)。宫颈癌Ⅰ、Ⅱ期患者生存素、活素和CD44v6蛋白的阳性表达率均低于Ⅲ、Ⅳ期(P<0.01);低分化病理分级患者生存素、活素和CD44v6蛋白的阳性表达率均明显高于高分化及中分化患者(P<0.01);有淋巴结转移患者生存素、活素和CD44v6蛋白的阳性表达率均明显高于无淋巴结转移患者(P<0.01);鳞癌患者生存素、活素和CD44v6蛋白的阳性表达率均显著高于腺癌患者(P<0.01)。结论:生存素、活素和CD44v6蛋白在宫颈癌及宫颈上皮内瘤变患者宫颈组织中呈特异性高水平表达,且与恶性程度成正比,可根据三者的表达水平来鉴别诊断宫颈癌与癌前病变。
Objective: To analyze and evaluate the expression and clinical significance of survivin, activin and CD44v6 protein in cervical cancer. Methods: Cervical specimens from 68 cases of cervical cancer, 69 cases of cervical intraepithelial neoplasia and 80 cases of normal cervical tissue samples were collected. The expressions of survivin, activin and CD44v6 protein were detected by immunohistochemistry. Results: The positive rates of survivin, survivin and CD44v6 protein in cervical cancer patients were the highest, followed by those with cervical intraepithelial neoplasia, the lowest in normal cervical tissues, the difference was statistically significant (all P <0.01) . The positive rates of survivin, survivin and CD44v6 in patients with stage Ⅰ and Ⅱ cervical cancer were lower than those in stage Ⅲ and Ⅳ (P <0.01). The positive rates of survivin, survivin and CD44v6 in poorly differentiated pathological grade were (P <0.01). The positive rates of survivin, survivin and CD44v6 protein in patients with lymph node metastasis were significantly higher than those without lymph node metastasis (P <0.01). Survivin , The positive expression rates of survivin and CD44v6 protein were significantly higher than those of adenocarcinoma patients (P <0.01). CONCLUSION: Survivin, biotin and CD44v6 protein are highly expressed in cervical cancer and cervical intraepithelial neoplasia, and are directly proportional to the degree of malignancy. According to the expression levels of survivin, CD44v6, Precancerous lesions.