在过去二十多年里,家族性腺瘤性息肉病(Familial Adenomatous Polyposis,FAP)的一个呈轻度病程的亚型—衰减型家族性腺瘤性息肉病(Attenuated Familial Adenomatous Polyposis,AFAP)被提出。AFAP作为一种疾病并未明确定义。关于AFAP的报道大部分都只处理几个家系,并且诊断标准和研究方法明显不同。与FAP相比,AFAP的主要特征是结直肠腺瘤数小于100且直肠腺瘤稀少, For the past two decades or more, Attenuated Familial Adenomatous Polyposis (AFAP) has been proposed as a mild course of familial Adenomatous Polyposis (FAP). AFAP as a disease is not clearly defined. Most reports on AFAP deal with only a few families, and the diagnostic criteria and research methods are significantly different. Compared with FAP, the main features of AFAP is that the number of colorectal adenomas is less than 100 and the number of rectal adenomas is sparse,