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聚唾液酸(PSA)经环氧氯丙烷活化后,与透明质酸(HA)在碱性条件下反应合成了系列PSA-HA接枝聚合物(P~1~P~5,PSA与HA质量比分别为1∶1~5∶1),合成率40%~89%,其结构经FT-IR,元素分析和SEM表征。以胰岛素为模型药物,将P~2与胰岛素按2∶1(m/m)混合时,包封率和载药率分别为85%和38%,平均粒径为3.2μm。体外释药试验结果表明:P~2对胰岛素有一定的体外缓释能力,在6 h内释药89%;在pH 1.2条件下的释药速度大于pH 7.4条件下的释药速度。
Poly (sialic acid) (PSA) was activated by epichlorohydrin and reacted with hyaluronic acid (HA) under basic condition to synthesize a series of PSA-HA graft polymers 1: 1 ~ 5: 1, respectively). The synthesis rate was 40% ~ 89%. The structure was characterized by FT-IR, elemental analysis and SEM. Taking insulin as a model drug, the encapsulation efficiency and drug loading rate were 85% and 38% when P ~ 2 and insulin were mixed by 2:1 (m / m), respectively. The average particle size was 3.2μm. In vitro release test results showed that: P ~ 2 has some sustained release of insulin in vitro release of 89% within 6 h; release rate at pH 1.2 is greater than the release rate of pH 7.4.