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目的对广西、云南、贵州3个产地的金樱子的根和根茎样品的免疫调节活性进行评价。方法采用小鼠迟发性超敏反应、小鼠溶血素抗体生成以及小鼠碳粒廓清试验,分别考察对细胞免疫、体液免疫和非特异性免疫的影响。结果金樱根提取物对于细胞免疫、体液免疫具有较明显的抑制作用,但对非特异性免疫反应作用不明显。金樱子不同药用部位(根和根茎)和不同产地(广西、贵州、云南)的受试样品在免疫活性调节方面的作用基本一致,无显著差异。结论不同部位和不同产地金樱子样品具有相似的的免疫抑制活性。
Objective To evaluate the immunomodulatory activity of rhizome and rhizome samples of Rosa laevigata in Guangxi, Yunnan and Guizhou. Methods The delayed hypersensitivity in mice, the formation of mouse hemolysin antibody and the carbon clearance test in mice were used to investigate the effects on cellular immunity, humoral immunity and nonspecific immunity. Results Jin Ying root extract on cellular immunity, humoral immunity has a significant inhibitory effect, but the non-specific immune response was not obvious. Rosa laevigata different medicinal parts (roots and rhizomes) and different origin (Guangxi, Guizhou, Yunnan) test samples in the regulation of immune activity basically the same, no significant difference. Conclusion The samples of Rosa laevigata in different parts and different areas have similar immunosuppressive activity.