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就具有抗炎作用的各种生药对大肠癌的癌前病变(大肠异常腺窝)的抑制作用进行了探讨。 取6周龄的F344雄性大鼠,皮下注射氧化偶氮甲烷(AOM)15mg/kg,每周1次,共2周。将生药提取物粉末以2%的浓度混入饲料中,从注射AOM的前一天开始喂饲。实验开始4周后摘出大肠,以福尔马林固定。将大肠以亚甲蓝染色后,检测大肠异常腺窝数。在所选的10种生药中,黄芩可使AOM诱发的
The inhibitory effects of various crude drugs with anti-inflammatory effects on the precancerous lesions (abnormal glandular fossa) of colorectal cancer were discussed. Six-week-old F344 male rats were subcutaneously injected with 15 mg/kg azoxymethane (AOM) once a week for 2 weeks. The crude drug extract powder was mixed into the feed at a concentration of 2% and fed from the day before the AOM injection. Four weeks after the start of the experiment, the large intestine was removed and fixed with formalin. After coloring the large intestine with methylene blue, the number of abnormal colorectal fossa was detected. Among the 10 selected crude drugs, Astragalus can induce AOM