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【目的】观察高压氧联合氟西汀在脑梗死后抑郁患者中的应用效果。【方法】选取本院2012年1月至2014年4月收治的90例卒中后抑郁患者，随机分为高压氧组、氟西汀组和联合组，每组30例；高压氧组和氟西汀组分别单独使用高压氧和氟西汀治疗，联合组使用高压氧联合氟西汀进行治疗，治疗6周后通过汉密尔顿抑郁量表（HAMD）和美国国立卫生院神经功能缺损评分（NIHSS）标准，对患者的抑郁程度和神经功能缺损情况进行评分。【结果】治疗6周后，联合组 HAMD得分为（13．19 ± 3．14），显著低于高压氧组和氟西汀组得分[（18．26±2．31）和（17．55±2．46）]，差异具有显著性（ P＜0．05）；联合组在NIHSS上得分为（6．5±3．8），也显著低于高压氧组和氟西汀组得分[（10．3±3．8）和（9．8±4．1）]，差异具有显著性（P ＜0．05）。【结论】高压氧联合氟西汀治疗脑梗死后抑郁疗效显著，值得推广使用。“,”Objective]To explore the effects of hyperbaric oxygen plus fluoxetine on depression after cere‐bral infarction patients .[Methods]A total of 90 patients with poststroke depression were selected from January 2012 to April 2014 and randomly divided into hyperbaric oxygen ,fluoxetine and treatment groups ( n = 30 each) .The hypertension and fluoxetine groups received hyperbaric oxygen and fluoxetine respectively while the treatment group had both .At Week 6 ,the degree of depressive patients and neural function were detected by Hamilton depression rating scale (HAMD) and the United States National Institutes of Health stroke Scale (NIHSS) .[Results]At Week 6 post‐treatment ,the HAMD scores of treatment ,hyperbaric oxygen and fluox‐etine groups were (13 .19 ± 3 .14) ,(18 .26 ± 2 .31) and (17 .55 ± 2 .46) respectively .And the difference was statistically significant( P <0 .05) .And the NIHSS score (6 .5 ± 3 .8) ,(10 .3 ± 3 .8) and (9 .8 ± 4 .1) respec‐tively .And the differences were statistically significant ( P<0 .05) .[Conclusion]Hyperbaric oxygen plus flu‐oxetine have marked efficacies for depression after cerebral infarction .And it is worthy of wider promotions .